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Established in 1998, the Princess Margaret Genomics Centre (PMGC) is a core lab facility providing access to high- quality, cost-effective research genomics services in support of biomedical and translational research. PMGC supports investigators from academic, clinical, and industry research environments at the local, national, and international level. PMGC is a research-only facility. We do not provide clinical diagnostic services or direct patient testing.
PMGC offers a broad portfolio of technologies, including DNA and RNA sequencing on Illumina platforms, epigenomics, panel-based profiling (Luminex and NanoString), functional genomics, single-cell and spatial multiomics. We also specialize in unique and custom techniques that aren’t found at most service providers. Investigators are encouraged to consult with our team to discuss project requirements, including custom assays not listed on the website.
In addition to laboratory services, PMGC provides end-to-end project support, working collaboratively with investigators on study design, experimental planning, technology selection, and sample preparation strategies. This consultative approach helps ensure that each project is matched with appropriate methodologies and produces high-quality, reproducible results.
As a public-facing core facility, PMGC is committed to make cutting edge and emerging genomics technologies more accessible and cost-effective to researchers here in Canada and the world.
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We provide several services for characterizing your RNA and
DNA samples, whether they are purified nucleic acids,
sequence ready libraries, or anything in between.
To submit samples for BioAnalyzer, please download
this form
and submit with your samples. For other quantification
services please contact a PMGC team member.
The PMGC houses a full suite of Illumina sequencing instruments including MiSeq (x2), NextSeq 500, NextSeq 2000, NovaSeq 6000 and NovaSeq X Plus. We perform library prep and sequencing services for a wide variety of assays. As for DNA microarrays, our service offerings are currently limited to DNA microarrays provided by Illumina.
Sequence-ready library types accepted:
| Whole Exome | ChIP | Micro-RNA |
| Whole Genome | ATAC | Cut&Run |
| Target capture panels | Methyl-Capture | Low/Hi-C |
| Bulk RNA Seq | MeDIP | 10x Genomics (all types) |
| RRBS | WGBS | CRISPR-Cas9 screens |
| Custom primer configurations | RIP-Seq | Inquire for others |
Library types that we can prepare and sequence from your nucleic acid samples:
| Whole Exome | Whole Genome | Target capture panels |
| CRISPR-Cas9 screens | Bulk RNA-Seq | ChIP (pulldown by client) |
| Micro-RNA | Illumina 5-Base DNA prep | Inquire for others |
Library types that we can prepare and sequence from cells/tissue:
| ATAC-Seq | CUT&RUN | Inquire for others |
Analyze gene expression and DNA mutations at single-cell resolution with our wide range of innovative technology offerings.
Spatial Omics integrates microscopy of tissue sections with readout of the transcriptome, proteins, and more. This allows one to collect information about the positional and phenotypic aspects of the cells whose transcriptional patterns are being interrogated. This novel technology is an extremely powerful extension of conventional histology!
Quantitative panel-based gene and protein expression assays from Nanostring and Luminex.
The PMGC has a team dedicated to validating and performing standard and emerging epigenomic and genome conformation assays. If you have an interest in an assay not listed below, contact our team to discuss.
Use genome and transcriptome editing tools such as CRISPR, CRISPRi, CRISPRa, and others to interrogate gene function.
No. PMGC provides genomics research services only and does not perform diagnostic genetic testing on patient samples for clinical decisions.
Yes. PMGC collaborates with academic investigators and industry partners on genomics research projects.
To receive a pricing estimate, contact the PMGC team with details about your project and the services or assays you are interested in. We can provide cost estimates for different assay options to help determine the most suitable approach for your research.
After the assay type, projected sample volume, and expected submission timeline have been finalized, PMGC will issue a formal quotation that includes the agreed-upon services, estimated costs, and payment requirements. The quotation must be reviewed and signed before samples are submitted for processing.
For all quotation, pricing, invoice, billing, and Purchase Order inquiries, please contact Julissa Tsao.
Samples should generally be shipped on dry ice, but requirements depend on the assay and sample type.
Within Canada, we recommend overnight priority shipping.
Our shipping address is:
For publications resulting from our services, please acknowledge the Princess Margaret Genomics Centre (pmgenomics.ca) in the Acknowledgements section of your manuscript. Acknowledgements are an important reflection of our contributions to your published work, and help strengthen our applications for grant funding. We appreciate your acknowledgements!
In general, it is sufficient to reference pmgenomics.ca and/or Princess Margaret Genomics Centre for tracking and reporting purposes. It is not required that Individual team members be named unless they have made a direct scientific contribution to your work that warrants authorship or specific acknowledgement.
To support accurate tracking of core facility usage in publications, please include the following Research Resource Identifier (RRID):
* A Research Resource Identifier (RRID) is a unique citation code that enables transparent reporting and recognition of core facilities in published research.
The Princess Margaret Genomics Centre is located at:
Allan Slaight Medical Innovation Labs
101 College Street, Rm 9-805
Toronto, Ontario, M5G 1L7
Canada
Phone:
(416) 634-8816
Email:
geneservice@pmgenomics.ca
LinkedIn:
princess-margaret-genomics-centre
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