Description
A 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione that has (R)-configuration. A synthetic small molecule which was under development for the treatment of type 1 diabetes mellitus.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C13H20N4O3 | 0 | 280.328 |
-lisofylline.svg)
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione | C=12N(C=NC1N(C(N(C2=O)CCCC[C@H](O)C)=O)C)C | InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1 | NSMXQKNUPPXBRG-SECBINFHSA-N |
|
Citations
- 2002. Randomized, placebo-controlled trial of lisofylline for early treatment of acute lung injury and acute respiratory distress syndrome. Critical Care Medicine. 30(1).
- George, CL, et al. 1999. Effects of lisofylline on hyperoxia-induced lung injury. The American Journal of Physiology. 276(5).
- Italiya, KS, et al. 2018. Self-assembling lisofylline-fatty acid conjugate for effective treatment of diabetes mellitus. Nanomedicine : Nanotechnology, Biology, and Medicine. 15(1).
- Rice, GC, et al. 1994. CT-1501R selectively inhibits induced inflammatory monokines in human whole blood ex vivo. Shock (Augusta, Ga.). 1(4).
- Wyska, E, et al. 2015. Physiologically based modeling of lisofylline pharmacokinetics following intravenous administration in mice. European Journal of Drug Metabolism and Pharmacokinetics. 41(4).
- Yang, Z, et al. 2003. The novel anti-inflammatory compound, lisofylline, prevents diabetes in multiple low-dose streptozotocin-treated mice. Pancreas. 26(4).
- Yang, Z, et al. 2004. Lisofylline: a potential lead for the treatment of diabetes. Biochemical Pharmacology. 69(1).
- Yang, ZD, et al. 2002. The anti-inflammatory compound lisofylline prevents Type I diabetes in non-obese diabetic mice. Diabetologia. 45(9).
- Świerczek, A, et al. 2017. PK/PD studies on non-selective PDE inhibitors in rats using cAMP as a marker of pharmacological response. Naunyn-Schmiedeberg's Archives of Pharmacology. 390(10).