DNAmod: 3-methylguanine

Description

A methylguanine carrying the methyl substituent at position 3.

Chemical properties

Chemical formula	Net charge	Average mass
C6H7N5O	0	165.153

Recommended notation

Name	3-methylguanine
Abbreviation	3mG

Nature

Origin	Function	Functional detail	Organisms	References
natural	damage	mutagenic	Escherichia coli Mesocricetus auratus Mus musculus	Margison, GP, et al. 1976. Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine. The Biochemical Journal. 157(3). Lawley, PD, et al. 1976. Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate. Chemico-biological Interactions. 12(2). Frei, JV, et al. 1978. Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma Some applications of high-pressure liquid chromatography. The Biochemical Journal. 174(3). Mielecki, D, et al. 2014. Ada response - a strategy for repair of alkylated DNA in bacteria. FEMS Microbiology Letters. 355(1).

Database references:

CHEBI:1604

Citations

Frei, JV, et al. 1978. Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography. The Biochemical Journal. 174(3).
Lawley, PD, et al. 1976. Removal of minor methylation products 7-methyladenine and 3-methylguanine from DNA of Escherichia coli treated with dimethyl sulphate. Chemico-biological Interactions. 12(2).
Margison, GP, et al. 1976. Methylated purines in the deoxyribonucleic acid of various Syrian-golden-hamster tissues after administration of a hepatocarcinogenic dose of dimethylnitrosamine. The Biochemical Journal. 157(3).
Mielecki, D, et al. 2014. Ada response - a strategy for repair of alkylated DNA in bacteria. FEMS Microbiology Letters. 355(1).
Porcelli, B, et al. 1997. Fast-atom bombardment mass spectrometry for mapping of endogenous methylated purine bases in urine extracts. Rapid Communications in Mass Spectrometry : RCM. 11(4).