Description
A nucleoside analogue that is 2'-deoxyuridine in which the hydrogen at position 5 on the uracil ring is replaced by a carboxy group.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C10H12N2O7 | 0 | 272.212 |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 5-carboxy-2'-deoxyuridine | [C@@H]1(N2C(NC(=O)C(=C2)C(=O)O)=O)O[C@H](CO)[C@H](C1)O | InChI=1S/C10H12N2O7/c13-3-6-5(14)1-7(19-6)12-2-4(9(16)17)8(15)11-10(12)18/h2,5-7,13-14H,1,3H2,(H,16,17)(H,11,15,18)/t5-,6+,7+/m0/s1 | GAGYTXTVUMXAOC-RRKCRQDMSA-N |
|
Citations
- Clough, DW, et al. 1978. Biological effects of 5-carboxy-2'-deoxyuridine: hydrolysis product of 5-trifluoromethyl-2'-deoxyuridine. Antimicrobial Agents and Chemotherapy. 14(1).
- Guerniou, V, et al. 2003. New synthesis of 5-carboxy-2'-deoxyuridine and its incorporation into synthetic oligonucleotides. Nucleosides, Nucleotides & Nucleic Acids. 22(5-8).
- Isenberg, N, et al. 1967. Synthesis of 5-carboxy-2'-deoxyuridine. Journal of Medicinal Chemistry. 10(5).
- Jones, MF, et al. 1981. The stability of trifluorothymidine: hydrolysis in buffered aqueous solutions. The Journal of Pharmacy and Pharmacology. 33(5).
- Karr, JR, et al. 2012. A whole-cell computational model predicts phenotype from genotype. Cell. 150(2).
- Pavan-Langston, D, et al. 1979. Intraocular penetration of trifluridine. American Journal of Ophthalmology. 87(6).