Description
A methylguanine in which the methyl group is located at the N2-position.
Chemical properties
| Chemical formula | Net charge | Average mass |
|---|---|---|
| C6H7N5O | 0 | 165.153 |
-methylguanine.svg)
Recommended notation
| Name | 2-methylguanine |
|---|---|
| Abbreviation | 2mG |
Nomenclature
| IUPAC | SMILES | InChI | InChIKey | Synonyms |
|---|---|---|---|---|
| 2-(methylamino)-1,7-dihydro-6H-purin-6-one | O=C1N=C(NC=2NC=NC21)NC | InChI=1S/C6H7N5O/c1-7-6-10-4-3(5(12)11-6)8-2-9-4/h2H,1H3,(H3,7,8,9,10,11,12) | SGSSKEDGVONRGC-UHFFFAOYSA-N |
|
Nature
| Origin | Function | Functional detail |
Organisms
|
References |
|---|---|---|---|---|
| natural | damage | mutagenic | Homo sapiens |
|
Citations
- Culp, LA, et al. 1970. Methylated bases in DNA of animal origin. Archives of Biochemistry and Biophysics. 136(1).
- Ho, Y, et al. 1974. On the methylated purine content of tRNA present in tumours. British Journal of Cancer. 29(4).
- Lesnyak, DV, et al. 2006. Methyltransferase that modifies guanine 966 of the 16 S rRNA: functional identification and tertiary structure. The Journal of Biological Chemistry. 282(8).
- Li, D, et al. 2013. Removal of N-alkyl modifications from N(2)-alkylguanine and N(4)-alkylcytosine in DNA by the adaptive response protein AlkB. Chemical Research in Toxicology. 26(8).
- Okada, K, et al. 2009. Production of yeast (m2G10) methyltransferase (Trm11 and Trm112 complex) in a wheat germ cell-free translation system. Nucleic Acids Symposium Series (2004). (53).
- Pegg, AE, et al. 1972. Studies of the ethylation of rat liver transfer ribonucleic acid after administration of L-ethionine. The Biochemical Journal. 128(1).
- Shrivastav, N, et al. 2014. A chemical genetics analysis of the roles of bypass polymerase DinB and DNA repair protein AlkB in processing N2-alkylguanine lesions in vivo. PloS One. 9(4).
- von Ahsen, U, et al. 1995. Identification of bases in 16S rRNA essential for tRNA binding at the 30S ribosomal P site. Science (New York, N.Y.). 267(5195).