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Citations

• Ahn, H, et al. 2007. Synthesis and evaluation of cis-1-[4-(hydroxymethyl)-2-cyclopenten-1-yl]-5-[(124)I]iodouracil: a new potential PET imaging agent for HSV1-tk expression. Journal of Medicinal Chemistry. 50(24).
• Ashton, WT, et al. 1988. Synthesis and antiherpetic activity of (+/-)-9-[[(Z)-2-(hydroxymethyl)cyclopropyl]methyl]guanine and related compounds. Journal of Medicinal Chemistry. 31(12).
• Ashton, WT, et al. 1985. Synthesis and antiherpetic activity of (S)-, (R)-, and (+/-)-9-[(2,3-dihydroxy-1-propoxy)methyl]guanine, linear isomers of 2'-nor-2'-deoxyguanosine. Journal of Medicinal Chemistry. 28(7).
• Baraldi, PG, et al. 2001. Design, synthesis, DNA binding, and biological evaluation of water-soluble hybrid molecules containing two pyrazole analogues of the alkylating cyclopropylpyrroloindole (CPI) subunit of the antitumor agent CC-1065 and polypyrrole minor groove binders. Journal of Medicinal Chemistry. 44(16).
• Barbarić, M, et al. 2005. Synthesis, X-ray crystal structure study, and cytostatic and antiviral evaluation of the novel cycloalkyl-N-aryl-hydroxamic acids. Journal of Medicinal Chemistry. 48(3).
• Barral, K, et al. 2003. Synthesis and antiviral evaluation of 3-hydroxy-2-methylpyridin-4-one dideoxynucleoside derivatives. Bioorganic & Medicinal Chemistry Letters. 13(24).
• Barral, K, et al. 2005. Synthesis and antiviral evaluation of cis-substituted cyclohexenyl and cyclohexanyl nucleosides. Journal of Medicinal Chemistry. 48(2).
• Barral, K, et al. 2006. Synthesis and antiviral evaluation of cyclic and acyclic 2-methyl-3-hydroxy-4-pyridinone nucleoside derivatives. Journal of Medicinal Chemistry. 49(1).
• Barral, K, et al. 2006. Synthesis, in vitro antiviral evaluation, and stability studies of novel alpha-borano-nucleotide analogues of 9-[2-(phosphonomethoxy)ethyl]adenine and (R)-9-[2-(phosphonomethoxy)propyl]adenine. Journal of Medicinal Chemistry. 49(26).
• Bas, D, et al. 2002. Rational determination of transfer free energies of small drugs across the water-oil interface. Journal of Medicinal Chemistry. 45(1).
• Beauchamp, LM, et al. 1988. Effect of acyclic pyrimidines related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine on herpesviruses. Journal of Medicinal Chemistry. 31(1).
• Bennett, SM, et al. 1990. Synthesis and antiviral activity of some acyclic and C-acyclic pyrrolo[2,3-d]pyrimidine nucleoside analogues. Journal of Medicinal Chemistry. 33(8).
• Bhattacharya, BK, et al. 1995. Synthesis and anti-DNA viral activities in vitro of certain 2,4-disubstituted-7-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)pyrrolo[2,3-d d pyrimidine nucleosides. Journal of Medicinal Chemistry. 38(20).
• Bisacchi, GS, et al. 1991. Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogues. Journal of Medicinal Chemistry. 34(4).
• Borthwick, AD, et al. 2003. Design and synthesis of pyrrolidine-5,5'-trans-lactams (5-oxo-hexahydropyrrolo[3,2-b]pyrroles) as novel mechanism-based inhibitors of human cytomegalovirus protease. 4. Antiviral activity and plasma stability. Journal of Medicinal Chemistry. 46(21).
• Boryski, J, et al. 1991. Synthesis and antiviral activity of 3-substituted derivatives of 3,9-dihydro-9-oxo-5H-imidazo[1,2-a]purines, tricyclic analogues of acyclovir and ganciclovir. Journal of Medicinal Chemistry. 34(8).
• Bronson, JJ, et al. 1989. Synthesis and antiviral activity of the nucleotide analogue (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]cytosine. Journal of Medicinal Chemistry. 32(7).
• Chamberlain, SD, et al. 1994. An enantiospecific synthesis of the human cytomegalovirus antiviral agent [(R)-3-((2-amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy)-4- hydroxybutyl]phosphonic acid. Journal of Medicinal Chemistry. 37(9).
• Chan, L, et al. 1999. Discovery of 1,6-naphthyridines as a novel class of potent and selective human cytomegalovirus inhibitors. Journal of Medicinal Chemistry. 42(16).
• Chan, L, et al. 2000. Design and evaluation of dihydroisoquinolines as potent and orally bioavailable human cytomegalovirus inhibitors. Bioorganic & Medicinal Chemistry Letters. 10(13).
• Chen, JJ, et al. 2000. Synthesis and antiviral evaluation of trisubstituted indole N-nucleosides as analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole (TCRB). Journal of Medicinal Chemistry. 43(12).
• Chen, X, et al. 2007. SAR studies on a novel series of human cytomegalovirus primase inhibitors. Bioorganic & Medicinal Chemistry Letters. 17(8).
• Chien, TC, et al. 2004. Synthesis and antiviral evaluation of polyhalogenated imidazole nucleosides: dimensional analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole. Journal of Medicinal Chemistry. 47(23).
• Cristofoli, WA, et al. 2007. 5-alkynyl analogs of arabinouridine and 2'-deoxyuridine: cytostatic activity against herpes simplex virus and varicella-zoster thymidine kinase gene-transfected cells. Journal of Medicinal Chemistry. 50(12).
• Cushing, TD, et al. 2006. Discovery of a novel series of inhibitors of human cytomegalovirus primase. Bioorganic & Medicinal Chemistry Letters. 16(18).
• Devivar, RV, et al. 1994. Benzimidazole ribonucleosides: design, synthesis, and antiviral activity of certain 2-(alkylthio)- and 2-(benzylthio)-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazoles. Journal of Medicinal Chemistry. 37(18).
• Eriksson, U, et al. 2006. Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir. Bioorganic & Medicinal Chemistry Letters. 17(3).
• Falardeau, G, et al. 2005. Design and synthesis of a potent macrocyclic 1,6-naphthyridine anti-human cytomegalovirus (HCMV) inhibitors. Bioorganic & Medicinal Chemistry Letters. 15(6).
• Farrow, SN, et al. 1990. Synthesis and biological properties of novel phosphotriesters: a new approach to the introduction of biologically active nucleotides into cells. Journal of Medicinal Chemistry. 33(5).
• Fedorov, II, et al. 1997. Novel 3'-C/N-substituted 2',3'-beta-D-dideoxynucleosides as potential chemotherapeutic agents. 1. Thymidine derivatives: synthesis, structure, and broad spectrum antiviral properties. Journal of Medicinal Chemistry. 40(4).
• Focher, F, et al. 2007. Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrobial Agents and Chemotherapy. 51(6).
• Gazivoda, T, et al. 2006. The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of L-ascorbic acid: synthesis, cytostatic, and antiviral activity evaluations. Bioorganic & Medicinal Chemistry. 15(2).
• Gazivoda, T, et al. 2007. Synthesis and antiviral and cytostatic evaluations of the new C-5 substituted pyrimidine and furo[2,3-d]pyrimidine 4',5'-didehydro-L-ascorbic acid derivatives. Journal of Medicinal Chemistry. 50(17).
• Gerona-Navarro, G, et al. 2004. Synthesis and anti-HCMV activity of 1-acyl-beta-lactams and 1-acylazetidines derived from phenylalanine. Bioorganic & Medicinal Chemistry Letters. 14(9).
• Gerona-Navarro, G, et al. 2005. From 1-acyl-beta-lactam human cytomegalovirus protease inhibitors to 1-benzyloxycarbonylazetidines with improved antiviral activity. A straightforward approach to convert covalent to noncovalent inhibitors. Journal of Medicinal Chemistry. 48(7).
• Golankiewicz, B, et al. 2001. Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study. Journal of Medicinal Chemistry. 44(24).
• Golankiewicz, B, et al. 1994. Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity. Journal of Medicinal Chemistry. 37(19).
• Goslinski, T, et al. 2002. Synthesis and biological activity of strongly fluorescent tricyclic analogues of acyclovir and ganciclovir. Journal of Medicinal Chemistry. 45(23).
• Gudmundsson, KS, et al. 2000. Synthesis and antiviral evaluation of halogenated beta-D- and -L-erythrofuranosylbenzimidazoles. Journal of Medicinal Chemistry. 43(12).
• Gudmundsson, KS, et al. 2000. Synthesis of fluorosugar analogues of 2,5,6-trichloro-1-(beta-D-ribofuranosyl)benzimidazole as antivirals with potentially increased glycosidic bond stability. Journal of Medicinal Chemistry. 43(12).
• Gueiffier, A, et al. 1996. Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents. Journal of Medicinal Chemistry. 39(14).
• Gueiffier, A, et al. 1998. Synthesis of imidazo[1,2-a]pyridines as antiviral agents. Journal of Medicinal Chemistry. 41(25).
• Guenther, S, et al. 2002. A thymidine phosphorylase-stable analogue of BVDU with significant antiviral activity. Journal of Medicinal Chemistry. 45(25).
• Guillerm, G, et al. 2001. Synthesis, mechanism of action, and antiviral activity of a new series of covalent mechanism-based inhibitors of S-adenosyl-L-homocysteine hydrolase. Journal of Medicinal Chemistry. 44(17).
• Guillerm, G, et al. 2006. Inactivation of S-adenosyl-L-homocysteine hydrolase by 6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine and 6'-chloro-6'-cyano-5',6'-didehydro-6'-deoxyhomoadenosine. Antiviral and cytotoxic effects. Journal of Medicinal Chemistry. 49(4).
• Gupta, PK, et al. 1989. Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin. Journal of Medicinal Chemistry. 32(7).
• Gupta, PK, et al. 1989. Synthesis, cytotoxicity, and antiviral activity of some acyclic analogues of the pyrrolo[2,3-d]pyrimidine nucleoside antibiotics tubercidin, toyocamycin, and sangivamycin. Journal of Medicinal Chemistry. 32(2).
• Hayashi, K, et al. 2007. Antiviral activity of berberine and related compounds against human cytomegalovirus. Bioorganic & Medicinal Chemistry Letters. 17(6).
• Herdewijn, P, et al. 2001. The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides. Bioorganic & Medicinal Chemistry Letters. 11(12).
• Hernandez, AI, et al. 2006. N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. Journal of Medicinal Chemistry. 49(26).
• Hyde, RM, et al. 2003. Antiviral amphipathic oligo- and polyribonucleotides: analogue development and biological studies. Journal of Medicinal Chemistry. 46(10).
• Jeong, LS, et al. 2001. Syntheses and structure--activity relationships of novel apio and thioapio dideoxydidehydronucleosides as anti-HCMV agents. Journal of Medicinal Chemistry. 44(5).
• Jeong, LS, et al. 1999. Synthesis and antiviral activity of novel isodideoxy nucleosides with exocyclic methylene. Bioorganic & Medicinal Chemistry Letters. 8(7).
• Kim, A, et al. 2006. Synthesis and antiviral activity of C-fluoro-branched cyclopropyl nucleosides. European Journal of Medicinal Chemistry. 42(4).
• Kim, CU, et al. 1990. Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine. Journal of Medicinal Chemistry. 33(6).
• Kim, DK, et al. 1999. Synthesis and evaluation of 2-amino-9-(1, 3-dihydroxy-2-propoxymethyl)- 6-fluoropurine mono- and diesters as potential prodrugs of ganciclovir. Journal of Medicinal Chemistry. 42(2).
• Kim, HO, et al. 2001. Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines. Bioorganic & Medicinal Chemistry Letters. 11(4).
• Kolocouris, A, et al. 2002. New 2-(1-adamantylcarbonyl)pyridine and 1-acetyladamantane thiosemicarbazones-thiocarbonohydrazones: cell growth inhibitory, antiviral and antimicrobial activity evaluation. Bioorganic & Medicinal Chemistry Letters. 12(5).
• Kolocouris, N, et al. 1996. Synthesis and antiviral activity evaluation of some new aminoadamantane derivatives. 2. Journal of Medicinal Chemistry. 39(17).
• Krawczyk, SH, et al. 1990. Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections. Journal of Medicinal Chemistry. 33(12).
• Krawczyk, SH, et al. 1995. Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin. Journal of Medicinal Chemistry. 38(20).
• Krawczyk, SH, et al. 1995. Synthesis and evaluation of certain thiosangivamycin analogs as potential inhibitors of cell proliferation and human cytomegalovirus. Journal of Medicinal Chemistry. 38(20).
• Krecmerová, M, et al. 2007. Antiviral activity of triazine analogues of 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (cidofovir) and related compounds. Journal of Medicinal Chemistry. 50(5).
• Krecmerová, M, et al. 2007. Ester prodrugs of cyclic 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-azacytosine: synthesis and antiviral activity. Journal of Medicinal Chemistry. 50(23).
• Kumar, R, et al. 2001. Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides. Journal of Medicinal Chemistry. 44(21).
• Kumar, R, et al. 2001. Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity. Bioorganic & Medicinal Chemistry Letters. 11(22).
• Kumar, R, et al. 2001. Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils. Journal of Medicinal Chemistry. 44(24).
• Kumar, R, et al. 2002. 5-Bromo (or chloro)-6-azido-5,6-dihydro-2' -deoxyuridine and -thymidine derivatives with potent antiviral activity. Bioorganic & Medicinal Chemistry Letters. 12(3).
• Kumar, R, et al. 2002. Design and synthesis of novel 5-substituted acyclic pyrimidine nucleosides as potent and selective inhibitors of hepatitis B virus. Journal of Medicinal Chemistry. 45(10).
• Kumar, R, et al. 2006. Effect of various pyrimidines possessing the 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2'-deoxyribose, on wild-type and mutant hepatitis B virus replication. Journal of Medicinal Chemistry. 49(12).
• Kumar, R, et al. 1993. Synthesis and antiviral activity of novel 5-(1-azido-2-haloethyl) and 5-(1-azido-, amino-, or methoxyethyl) analogs of 2'-deoxyuridine. Journal of Medicinal Chemistry. 36(17).
• Larsen, SD, et al. 2007. 7-Oxo-4,7-dihydrothieno[3,2-b]pyridine-6-carboxamides: synthesis and biological activity of a new class of highly potent inhibitors of human cytomegalovirus DNA polymerase. Bioorganic & Medicinal Chemistry Letters. 17(14).
• Legraverend, M, et al. 1990. Synthesis of new (+-)-3,5-dihydroxypentyl nucleoside analogues from 1-amino-5-(benzyloxy)pentan-3-ol and their antiviral evaluation. Journal of Medicinal Chemistry. 33(9).
• Li, C, et al. 2007. Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine. Bioorganic & Medicinal Chemistry. 16(5).
• Lin, JS, et al. 1999. Structure-activity relationships of L-dioxolane uracil nucleosides as anti-Epstein Barr virus agents. Journal of Medicinal Chemistry. 42(12).
• Lombardo, F, et al. 1996. Computation of brain-blood partitioning of organic solutes via free energy calculations. Journal of Medicinal Chemistry. 39(24).
• Madhavan, GV, et al. 1988. Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase. Journal of Medicinal Chemistry. 31(9).
• Martin, JC, et al. 1986. Synthesis and anti-herpes-virus activity of acyclic 2'-deoxyguanosine analogues related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine. Journal of Medicinal Chemistry. 29(8).
• Martin, JC, et al. 1985. Acyclic analogues of 2'-deoxynucleosides related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine as potential antiviral agents. Journal of Medicinal Chemistry. 28(3).
• Martinez, A, et al. 1999. Novel potential agents for human cytomegalovirus infection: synthesis and antiviral activity evaluation of benzothiadiazine dioxide acyclonucleosides. Journal of Medicinal Chemistry. 42(7).
• Martinez, A, et al. 1999. Chlorophenylmethyl benzothiadiazine dioxides derivatives: potent human cytomegalovirus inhibitors. Bioorganic & Medicinal Chemistry Letters. 9(21).
• Martinez, A, et al. 2000. Benzothiadiazine dioxide dibenzyl derivatives as potent human cytomegalovirus inhibitors: synthesis and comparative molecular field analysis. Journal of Medicinal Chemistry. 43(17).
• Martinez, A, et al. 2000. Nonnucleoside human cytomegalovirus inhibitors: synthesis and antiviral evaluation of (chlorophenylmethyl)benzothiadiazine dioxide derivatives. Journal of Medicinal Chemistry. 43(17).
• Maslen, HL, et al. 2004. 6-azapyrimidine-2'-deoxy-4'-thionucleosides: antiviral agents against TK+ and TK- HSV and VZV strains. Journal of Medicinal Chemistry. 47(22).
• Matsson, P, et al. 2005. Exploring the role of different drug transport routes in permeability screening. Journal of Medicinal Chemistry. 48(2).
• McGee, DP, et al. 1985. Synthesis and antiherpes simplex virus activity of 9-[(1,3-dihydroxy-2-propylthio)methyl]guanine. Journal of Medicinal Chemistry. 28(9).
• McGuigan, C, et al. 2003. Novel bicyclic furanopyrimidines with dual anti-VZV and -HCMV activity. Bioorganic & Medicinal Chemistry Letters. 13(24).
• McGuigan, C, et al. 2004. Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism. Journal of Medicinal Chemistry. 47(7).
• Meade, EA, et al. 1992. Synthesis, antiproliferative, and antiviral activity of certain 4-aminopyrrolo[2,3-d]pyridazine nucleosides: an entry into a novel series of adenosine analogues. Journal of Medicinal Chemistry. 35(3).
• Meade, EA, et al. 1993. Synthesis, antiproliferative, and antiviral activity of 4-amino-1-(beta-D-ribofuranosyl)pyrrolo[2,3-d]pyridazin-7(6H)-one and related derivatives. Journal of Medicinal Chemistry. 36(24).
• Meade, EA, et al. 1997. Synthesis and antiproliferative and antiviral activity of carbohydrate-modified pyrrolo[2,3-d]pyridazin-7-one nucleosides. Journal of Medicinal Chemistry. 40(5).
• Medveczky, M, et al. 1995. Haloanilino derivatives of pyrimidines, purines, and purine nucleoside analogs: synthesis and activity against human cytomegalovirus. Journal of Medicinal Chemistry. 38(10).
• Migawa, MT, et al. 1998. Design, synthesis, and antiviral activity of alpha-nucleosides: D- and L-isomers of lyxofuranosyl- and (5-deoxylyxofuranosyl)benzimidazoles. Journal of Medicinal Chemistry. 41(8).
• Nguyen-Ba, P, et al. 1999. Design and synthesis of a novel class of nucleotide analogs with anti-HCMV activity. Bioorganic & Medicinal Chemistry Letters. 8(24).
• Nguyen-Ba, P, et al. 1999. Identification of novel nucleotide phosphonate analogs with potent anti-HCMV activity. Bioorganic & Medicinal Chemistry Letters. 8(24).
• Norbeck, DW, et al. 1990. Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS. Journal of Medicinal Chemistry. 33(5).
• Ohtawa, M, et al. 2007. 9-(2-C-Cyano-2-deoxy-beta-D-arabino-pentofuranosyl)guanine, a potential antitumor agent against B-lymphoma infected with Kaposi's sarcoma-associated herpesvirus. Journal of Medicinal Chemistry. 50(9).
• Opacić, N, et al. 2005. The novel L- and D-amino acid derivatives of hydroxyurea and hydantoins: synthesis, X-ray crystal structure study, and cytostatic and antiviral activity evaluations. Journal of Medicinal Chemistry. 48(2).
• Patil, SD, et al. 1992. (+-)-carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties. Journal of Medicinal Chemistry. 35(12).
• Peterson, ML, et al. 1990. Synthesis and biological evaluation of carbocyclic analogues of lyxofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines. Journal of Medicinal Chemistry. 33(4).
• Prekupec, S, et al. 2007. Novel C-6 fluorinated acyclic side chain pyrimidine derivatives: synthesis, (1)H and (13)C NMR conformational studies, and antiviral and cytostatic evaluations. Journal of Medicinal Chemistry. 50(13).
• Prisbe, EJ, et al. 1986. Synthesis and antiherpes virus activity of phosphate and phosphonate derivatives of 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine. Journal of Medicinal Chemistry. 29(5).
• Pudlo, JS, et al. 1990. Synthesis, antiproliferative, and antiviral activity of certain 4-substituted and 4,5-disubstituted 7-[(1,3-dihydroxy-2-propoxy)methyl]pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry. 33(7).
• Pudlo, JS, et al. 1988. Synthesis and antiviral activity of certain 4- and 4,5-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry. 31(11).
• Qiu, YL, et al. 1998. (Z)- and (E)-2-((hydroxymethyl)cyclopropylidene)methyladenine and -guanine. New nucleoside analogues with a broad-spectrum antiviral activity. Journal of Medicinal Chemistry. 41(1).
• Raić-Malić, S, et al. 1999. Novel pyrimidine and purine derivatives of L-ascorbic acid: synthesis and biological evaluation. Journal of Medicinal Chemistry. 42(14).
• Renau, TE, et al. 1996. Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry. 39(18).
• Rescifina, A, et al. 2006. Synthesis and biological activity of isoxazolidinyl polycyclic aromatic hydrocarbons: potential DNA intercalators. Journal of Medicinal Chemistry. 49(2).
• Robins, MJ, et al. 2006. Synthesis and biological evaluation of 6-(alkyn-1-yl)furo[2,3-d]pyrimidin-2(3H)-one base and nucleoside derivatives. Journal of Medicinal Chemistry. 49(1).
• Robins, MJ, et al. 2007. Synthesis and antiviral evaluation of 6-(alkyl-heteroaryl)furo[2,3-d]pyrimidin-2(3H)-one nucleosides and analogues with ethynyl, ethenyl, and ethyl spacers at C6 of the furopyrimidine core. Journal of Medicinal Chemistry. 50(16).
• Russ, P, et al. 2003. Synthesis and biological evaluation of 5-substituted derivatives of the potent antiherpes agent (north)-methanocarbathymine. Journal of Medicinal Chemistry. 46(23).
• Saluja, S, et al. 1996. Structure-activity relationships among 2-substituted 5,6-dichloro-, 4,6-dichloro-, and 4,5-dichloro-1-[(2-hydroxyethoxy) methyl]- and -1-[(1,3-dihydroxy-2-propoxy) methyl]benzimidazoles. Journal of Medicinal Chemistry. 39(4).
• Saxena, NK, et al. 1990. Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin. Journal of Medicinal Chemistry. 33(7).
• Saxena, NK, et al. 1988. Synthesis and antiviral activity of certain 4-substituted and 2,4-disubstituted 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidines. Journal of Medicinal Chemistry. 31(8).
• Schnute, ME, et al. 2005. 4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases. Journal of Medicinal Chemistry. 48(18).
• Schnute, ME, et al. 2007. 2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases. Bioorganic & Medicinal Chemistry Letters. 17(12).
• Scott, GM, et al. 2006. Multidrug resistance conferred by novel DNA polymerase mutations in human cytomegalovirus isolates. Antimicrobial Agents and Chemotherapy. 51(1).
• Slater, MJ, et al. 2001. Synthesis of N-alkyl substituted indolocarbazoles as potent inhibitors of human cytomegalovirus replication. Bioorganic & Medicinal Chemistry Letters. 11(15).
• Tutonda, MG, et al. 1998. Antiviral oligo- and polyribonucleotides containing selected triazolo[2,3-a]purines. Journal of Medicinal Chemistry. 41(25).
• Vaillancourt, VA, et al. 2000. Naphthalene carboxamides as inhibitors of human cytomegalovirus DNA polymerase. Bioorganic & Medicinal Chemistry Letters. 10(18).
• Verheggen, I, et al. 1995. Synthesis, biological evaluation, and structure analysis of a series of new 1,5-anhydrohexitol nucleosides. Journal of Medicinal Chemistry. 38(5).
• Vince, R, et al. 1987. Synthesis and antiviral activity of carbocyclic analogues of xylofuranosides of 2-amino-6-substituted-purines and 2-amino-6-substituted-8-azapurines. Journal of Medicinal Chemistry. 30(11).
• Véron, JB, et al. 2007. Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV). Bioorganic & Medicinal Chemistry. 15(22).
• Walker, JA, et al. 1998. Synthesis and antiviral evaluation of certain novel pyrazinoic acid C-nucleosides. Journal of Medicinal Chemistry. 41(8).
• Wang, J, et al. 2000. The cyclohexene ring system as a furanose mimic: synthesis and antiviral activity of both enantiomers of cyclohexenylguanine. Journal of Medicinal Chemistry. 43(4).
• Williams, JD, et al. 2004. Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides. Journal of Medicinal Chemistry. 47(23).
• Williams, JD, et al. 2004. Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives. Journal of Medicinal Chemistry. 47(23).
• Williams, JD, et al. 2004. Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides. Journal of Medicinal Chemistry. 47(23).
• Yan, Z, et al. 2005. Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity. Journal of Medicinal Chemistry. 48(1).
• Yoshimura, Y, et al. 1997. A facile, alternative synthesis of 4'-thioarabinonucleosides and their biological activities. Journal of Medicinal Chemistry. 40(14).
• Yu, KL, et al. 1992. Synthesis and antiviral activity of methyl derivatives of 9-[2-(phosphonomethoxy)ethyl]guanine. Journal of Medicinal Chemistry. 35(16).
• Zhou, S, et al. 2004. Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides. Journal of Medicinal Chemistry. 47(3).
• Zhou, S, et al. 2004. (Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity. Journal of Medicinal Chemistry. 47(27).
• Zhou, S, et al. 2006. 9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1. Journal of Medicinal Chemistry. 49(20).
• Zhu, Z, et al. 2000. Design, synthesis, and biological evaluation of tricyclic nucleosides (dimensional probes) as analogues of certain antiviral polyhalogenated benzimidazole ribonucleosides. Journal of Medicinal Chemistry. 43(12).
• Zou, R, et al. 1996. Synthesis and antiviral evaluation of certain disubstituted benzimidazole ribonucleosides. Journal of Medicinal Chemistry. 39(18).
• Zou, R, et al. 1997. Design, synthesis, and antiviral evaluation of 2-substituted 4,5-dichloro- and 4,6-dichloro-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections. Journal of Medicinal Chemistry. 40(5).
• Zou, R, et al. 1997. Design, synthesis, and antiviral evaluation of 2-chloro-5,6-dihalo-1-beta-D-ribofuranosylbenzimidazoles as potential agents for human cytomegalovirus infections. Journal of Medicinal Chemistry. 40(5).